GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1056667 | 1 | rs6903973 | chr6:26499942 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4 | 7.43E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6903973 | chr6:26499942 | ZNF322A | chr6:26634612-26659963:- | -0.14 | -3.79 | 0.000169 | Educational attainment |
| THCA | cis | rs9371538 | 1 | rs6904133 | chr6:151881805 | C6orf97 | chr6:151815175-151942327:+ | 0.36 | 5 | 8.02E-7 | Bone mineral density (spine) |
| THCA | cis | rs12192947 | 1 | rs6904343 | chr6:24317666 | MRS2 | chr6:24403153-24425809:+ | 0.15 | 3.43 | 0.000645 | Uric acid levels |
| THCA | cis | rs7756935 | 1 | rs6904373 | chr6:46628067 | CYP39A1 | chr6:46517445-46620523:- | -0.32 | -4.93 | 1.14E-6 | Lipoprotein-associated phospholipase A2 activity and mass |
| THCA | cis | rs7762018 | 1 | rs6904601 | chr6:170131905 | C6orf70 | chr6:170151721-170181617:+ | 0.25 | 5.11 | 4.56E-7 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs7762018 | 1 | rs6904601 | chr6:170131905 | WDR27 | chr6:169857307-170102159:- | -0.18 | -5.54 | 5.0E-8 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs9346353 | 1 | rs6904680 | chr6:70453849 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.38 | 0.000787 | Sleep duration |
| THCA | cis | rs751728 | 1 | rs6904991 | chr6:33732262 | LEMD2 | chr6:33738991-33756906:- | -0.3 | -6.8 | 3.22E-11 | Crohn's disease |
| THCA | cis | rs853679 | 1 | rs6905391 | chr6:28262686 | ZKSCAN3 | chr6:28317691-28334523:+ | -0.26 | -5.15 | 3.75E-7 | Depression |
| THCA | cis | rs853679 | 1 | rs6905391 | chr6:28262686 | ZNF187 | chr6:28234788-28245978:+ | -0.3 | -6.08 | 2.53E-9 | Depression |
| THCA | cis | rs853679 | 1 | rs6905391 | chr6:28262686 | ZNF193 | chr6:28193067-28201260:+ | 0.19 | 3.52 | 0.000475 | Depression |
| THCA | cis | rs853679 | 1 | rs6905391 | chr6:28262686 | ZNF323 | chr6:28292517-28324048:- | 0.44 | 6.21 | 1.15E-9 | Depression |
| THCA | cis | rs853679 | 1 | rs6905391 | chr6:28262686 | ZNF389 | chr6:28129551-28137375:+ | -0.44 | -6.37 | 4.46E-10 | Depression |
| THCA | cis | rs853679 | 1 | rs6905391 | chr6:28262686 | ZSCAN23 | chr6:28393287-28411279:- | 0.22 | 4.83 | 1.88E-6 | Depression |